Author

B. M. T. Burgering

University Medical Center Utrecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

P. E. Polderman· 3 shared T. B. Dansen· 3 shared D. M. K. van Soest· 2 shared M. Meerlo· 2 shared S. De Henau· 2 shared Anneline S.J.M. te RieleiD· 1 shared Daphne van den Berg· 1 shared E. C. Brombacher· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

P. E. Polderman

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Author profile →

6 papers

Recent·Most cited

PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism

Su Ji Han, Daphne van den Berg, Hesther de Ruiter, Hoyee Tsui, Eirini Kyriakopoulou, Tim Koopmans, Ilaria Perini, Jantine Monshouwer‐Kloots, Sebastiaan J. van Kampen, Anneline S.J.M. te Riele, Ilse R. Kelters, Monica Gianoli, B. M. T. Burgering, Eva van Rooij

This study identifies reduced oxidative phosphorylation (OXPHOS) in PKP2 mutant cardiomyocytes due to lower PPARGC1A expression, suggesting PPARGC1A modulation as a potential therapeutic target for arrhythmogenic cardiomyopathy.

Cardiovascular Research · Jul 6, 2026Peer-reviewedMolecular Biology

Direct quantification of chemogenetic H2O2 production in live human cells.

W. T. F. den Toom, D. M. K. van Soest, P. E. Polderman, M. H. van Triest, L. J. M. Bruurs, B. M. T. Burgering, S. De Henau, T. B. Dansen

This paper introduces an assay to directly quantify DAAO-mediated H2O2 production in live human cells and compares it to mitochondrial respiration.

bioRxiv · May 3, 2023Cell Biology

Mitochondrial H2O2 release does not directly cause genomic DNA damage.

D. M. K. van Soest, P. E. Polderman, W. T. den Toom, S. Zwakenberg, S. De Henau, B. M. T. Burgering, T. B. Dansen

This study shows that mitochondrial H2O2 release does not directly cause genomic DNA damage, as it instead triggers ferroptosis and prevents mutation propagation.

bioRxiv · Mar 29, 2023Cell Biology

DNA damage and oxidizing conditions activate p53 through differential upstream signaling pathways.

T. Shi, P. E. Polderman, B. M. T. Burgering, T. B. Dansen

The paper investigates how oxidizing conditions activate p53 through two distinct pathways: DNA damage response and stress-activated kinases, showing they can operate independently.

bioRxiv · Sep 13, 2020Cell Biology

Calpain-2 regulates hypoxia/HIF-induced amoeboid reprogramming and metastasis

V. te Boekhorst, L. Jiang, M. Mahlen, M. Meerlo, G. Dunkel, F. C. Durst, Y. Yang, H. Levine, B. M. T. Burgering, P. Friedl

This study identifies calpain-2 as a regulator of hypoxia-induced amoeboid reprogramming and metastasis in breast and head and neck cancers.

bioRxiv · Jan 6, 2020 · PreprintCancer Biology

Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis

M. C. Ludikhuize, M. Meerlo, M. Pages Gallego, M. Burgaya Julia, N. T. B. Nguyen, E. C. Brombacher, J.-H. Paik, B. M. T. Burgering, M. J. Rodriguez Colman

The paper shows that FOXO and Notch signaling regulate mitochondrial fission, driving intestinal stem cell differentiation into secretory lineages through metabolic rewiring.

bioRxiv · Sep 20, 2019Cell Biology