Author

J.-H. Weng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

S. S. Taylor· 3 shared F. W. Herberg· 2 shared J. Wu· 2 shared P. C. Aoto· 2 shared S. H. Schmidt· 2 shared S. Knapp· 2 shared S. Mathea· 2 shared S. Silletti· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersBiochemistry

S. S. Taylor

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3 papers

Recent·Most cited

Capturing differences in the regulation of LRRK2 dynamics and conformational states by small molecule kinase inhibitors

J.-H. Weng, W. Ma, J. Wu, S. Silletti, J. A. McCammon, S. S. Taylor

This study uses simulations and HDX-MS to analyze how two LRRK2 inhibitors affect the protein's conformational dynamics and kinase activity.

bioRxiv · Oct 24, 2022Biochemistry

Two helices control the dynamic crosstalk between the catalytic domains of LRRK2

J.-H. Weng, P. C. Aoto, R. Lorenz, J. Wu, S. H. Schmidt, J. T. Manschwetus, P. Kaila-Sharma, S. Mathea, S. Knapp, F. W. Herberg, S. S. Taylor

The paper identifies two helices that regulate the conformation and function of the kinase domain in LRRK2 through dynamic crosstalk.

bioRxiv · Sep 29, 2021 · PreprintBiochemistry

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

S. H. Schmidt, J.-H. Weng, P. C. Aoto, D. Boassa, S. Mathea, S. Silletti, J. Hu, M. Wallbott, E. A. Komives, S. Knapp, F. W. Herberg, S. S. Taylor

This study investigates how Parkinson's Disease mutations affect LRRK2 activation and subcellular localization through conformational changes and domain interactions.

bioRxiv · Jul 13, 2020Biochemistry