eIF5a reduction via decreased Klf5 leads to cell senescence by mitochondrial fission in VSMCs
D. Ma, B. Zheng, H.-l. Liu, Y.-b. Zhao, X. Liu, X. Zhang, Q. Li, W.-b. Shi, T. Suzuki, J.-k. Wen
This study shows that Klf5 downregulation in VSMCs leads to mitochondrial fission and senescence by reducing eIF5a, which preserves mitochondrial integrity.
bioRxiv · Sep 30, 2019 · PreprintBiochemistry