The distinct biochemical property enables thymidylate kinase as a drug target and participates in pyrimidine drug sensitivity in Candida albicans
C. Y. Huang, Y.-C. Chen, B. A. Wu-Hsieh, J.-M. Fang, Z.-F. Chang, Yee-Chun Chen, Betty A. Wu-Hsieh, Jim-Min Fang and Zee-Fen Chang, Chang-Yu Huang
This study identifies a unique Ca-loop in C. albicans thymidylate kinase that contributes to drug sensitivity and highlights 5-FUrd as a potential antifungal drug.
bioRxiv · Nov 9, 2018 · PreprintBiochemistry