Author

Z.-F. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Y. Huang· 2 shared B. A. Wu-Hsieh· 1 shared C.-M. Hu· 1 shared H.-Y. Wang· 1 shared J.-M. Fang· 1 shared J.-M. Feng· 1 shared S.-Y. Wu· 1 shared T.-J. Yang· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

C. Y. Huang

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Targeting Reductive Metabolic Shifts by T315I Mutation in BCR-ABL Myeloid Leukemia for Therapy

C. Y. Huang, Y.-H. Chung, S.-Y. Wu, H.-Y. Wang, Z.-Y. Lin, T.-J. Yang, J.-M. Feng, C.-M. Hu, Z.-F. Chang

This study identifies metabolic shifts in T315I-Bcr-Abl CML and shows that combining JMF4073 with UK-5099 eradicates the disease in vivo.

bioRxiv · Mar 22, 2022 · PreprintCancer Biology

The distinct biochemical property enables thymidylate kinase as a drug target and participates in pyrimidine drug sensitivity in Candida albicans

C. Y. Huang, Y.-C. Chen, B. A. Wu-Hsieh, J.-M. Fang, Z.-F. Chang, Yee-Chun Chen, Betty A. Wu-Hsieh, Jim-Min Fang and Zee-Fen Chang, Chang-Yu Huang

This study identifies a unique Ca-loop in C. albicans thymidylate kinase that contributes to drug sensitivity and highlights 5-FUrd as a potential antifungal drug.

bioRxiv · Nov 9, 2018 · PreprintBiochemistry