Y.-C. Chen

Cynipid wasps systematically reprogram host metabolism and restructure cell walls in developing galls

This study investigates how Cynipid wasps alter plant metabolism and cell wall structure to form galls, revealing coordinated lignin and xylan deposition in gall vasculature.

Multifunctional biomimetic porphyrin-lipid nanoparticles - novel nanoscale theranostics for atherosclerotic cardiovascular disease

This paper develops Por-HDL-NPs for atherosclerosis theranostics, showing they reduce inflammation, promote cholesterol efflux, and visualize plaques via imaging.

Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

The paper investigates interactions between KRAB-ZNF genes and transposable elements in primate brains, finding increased interactions in humans and a link to Alzheimer's disease.

A Whole-Cell Screening Platform to Discover Cell Adhesion Molecules that Enable Programmable Bacterial Cell-Cell Adhesion

This paper introduces a whole-cell screening platform to identify cell adhesion molecules targeting bacterial membrane proteins, successfully discovering functional CAMs that recognize three outer membrane proteins.

MiR-221/222-enriched ADSC-exosome mitigates PM exposure-exacerbated cardiac ischemia/reperfusion injury through the modulation of the BNIP3/LC3B/PUMA pathway

This study shows that PM exposure worsens cardiac ischemia/reperfusion injury, which is mitigated by ADSC-exosome containing miR-221/222 through modulation of the BNIP3/LC3B/PUMA pathway.

Chromosome-level genome assemblies of two hemichordates provide new insights into deuterostome origin and chromosome evolution

This study presents chromosome-level genome assemblies of two hemichordates to infer deuterostome ancestral chromosomal architecture and lineage-specific modifications.

Uncovering the Roles of Mycobacterium tuberculosis melH in Redox and Bioenergetic Homeostasis: Implications for Antitubercular Therapy

This study investigates the role of melH in Mycobacterium tuberculosis and Mycobacterium marinum, showing its involvement in redox homeostasis, bioenergetics, and oxidative stress response, with implications for antitubercular drug development.

Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2

This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.

Phylonumtomics uncovers diverse evolutionary trajectories of mitogenomic fossils buried in mammalian and avian genomes

The paper identifies NUMTs with intact mitochondrial reading frames in mammalian and avian genomes, showing evidence of introgression in birds and selection in both groups, with some NUMTs showing signs of adaptive evolution.

An inducible germ cell ablation chicken model for high-grade germline chimeras

This paper develops a drug-inducible germ cell ablation system in chickens to improve the efficiency of generating germline chimeras through transplanted gene-edited primordial germ cells.

Deformable Cell-Like Microlasers for Real-Time Mechanical Quantification in Organoids

This paper develops deformable microlasers to quantify mechanical stress in organoids and spheroids with high resolution and real-time capability.

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

The paper investigates the structural and functional dynamics of the PP2A-B56δ holoenzyme, showing how mutations linked to intellectual disability affect its allosteric network and phosphorylation rates.

Vaccinia virus induces EMT-like transformation and RhoA-mediated mesenchymal migration

This study shows vaccinia virus induces EMT-like changes and RhoA-mediated mesenchymal migration in epithelial cells, facilitating viral spread.

Pancreatic Deletion of Mitogen-inducible Gene 6 Promotes Beta Cell Proliferation Following Destruction

This study shows that deleting Mig6 in pancreatic cells enhances beta cell proliferation and glucose tolerance after beta cell destruction in a T1D model.

Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Deficiency Exacerbates Alcohol-Induced Hepatic Oxidative Stress, Inflammation, Steatosis, and Fibrosis

This study shows that AKR1A1 deficiency worsens alcohol-induced liver damage by increasing oxidative stress, inflammation, steatosis, and fibrosis through 4-HNE/p53 signaling.

Microsecond pulse electrical stimulation modulates cell migration

This study introduces microsecond pulse electric field (sPEF) to enhance wound healing by promoting fibroblast migration and ECM alignment, validated in 2D and 3D models and a mouse wound healing assay.

Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice

This study shows that deleting CPE in beta cells disrupts proinsulin processing and alters beta cell identity, leading to impaired function and increased beta-cell area in mice.

A single dose of intravenous human amniotic membrane-derived mesenchymal stem cells limits transmural infarction, reduces fibrosis size, and improves left ventricular systolic function in the myocardial ischemic/reperfusion model of rats

Insights into deuterostome evolution from the biphasic transcriptional programmes of hemichordates

This study identifies a biphasic developmental program in hemichordates, revealing conserved gene regulatory networks and cis-regulatory elements across deuterostomes.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

The paper develops brain region-specific neural spheroids for disease modeling and drug screening, demonstrating their utility in Alzheimer's, Parkinson's, and Opioid Use Disorder.

Quantum CART (qCART), a piggyBac-based system for development and production of virus-free multiplex CAR-T cell therapy

The paper introduces a virus-free multiplex CAR-T cell therapy system called qCART, integrating four platforms to improve CAR-T development and manufacturing.

Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using qCART, the Quantum pBac-based CAR-T system

This paper demonstrates the efficient manufacturing of CD20/CD19 dual-targeted, iCasp9-regulatable CAR-TSCM cells using the virus-free qCART system, showing robust tumor eradication and safety.

Quantum pBac: An effective, high-capacity piggyBac-based gene integration vector system for unlocking gene therapy potential

This paper develops a virus-free gene therapy vector system, Quantum pBac, which improves transposition efficiency and payload capacity for CAR-T cell production.

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

This study shows SORLA reduces islet amyloid deposition by mediating endocytic uptake of proIAPP, preventing cell death in pancreatic beta cells.

Elevated islet prohormone ratios as indicators of insulin dependency in islet transplant recipients

The paper identifies elevated prohormone ratios as indicators of insulin dependency in islet transplant recipients using human and mouse models.

How big should this object be? Perceptual influences on viewing-size preferences

The paper investigates how perceptual preferences for object sizes are influenced by both semantic knowledge and visual features, showing that mid-level visual features can evoke size preferences independently of explicit knowledge.

Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents

The paper validates in vitro human lung tissue models for studying SARS-CoV-2 and influenza virus infections and antiviral treatments.

Single Cell Biological Microlasers Powered by Deep Learning

This study uses deep learning to predict cell sizes from laser mode imaging of single-cell lasers, demonstrating sub-wavelength accuracy in both synthetic and biological cell models.

Glucolipotoxicity-induced Mig6 desensitizes EGFR signaling and promotes pancreatic beta cell death

This study shows that Mig6, induced by glucolipotoxicity, inhibits EGFR signaling and promotes beta cell death in type 2 diabetes.