B.1.1.7 and B.1.351 variants are highly virulent in K18-ACE2 transgenic mice and show different pathogenic patterns from early SARS-CoV-2 strains
P. Radvak, H. J. Kwon, M. Kosikova, U. Ortega-Rodriguez, R. Xiang, J.-N. Phue, R.-F. Shen, J. Rozzelle, N. Kapoor, T. Rabara, J. Fairman, H. Xie
This study shows that B.1.1.7 and B.1.351 SARS-CoV-2 variants are more lethal than early strains in K18-hACE2 mice and cause distinct pathogenic effects.
bioRxiv · Jun 5, 2021Immunology