R. Daniels

Modernizing the original influenza vaccine to enhance protective antibody responses against neuraminidase antigens

This study enhances influenza vaccine efficacy by improving NA antibody responses through modified virions and recombinant NA proteins in a mouse model.

Thermoplasmonic induced vesicle fusion for investigating membrane protein phase affinity

The paper develops a method to study membrane protein phase affinity by transferring proteins from cells to model membranes and observing phase partitioning.

Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

Comparison of the neuraminidase antigenicity in recently circulating influenza A and vaccine viruses

The paper compares the antigenicity of neuraminidase (NA) from circulating influenza A viruses to vaccine strains, finding antigenic similarity and highlighting C-terminal substitutions affecting H3N2 NA reactivity.

Design of the recombinant influenza neuraminidase antigen is crucial for protective efficacy

This study evaluates how different designs of recombinant influenza neuraminidase (rNA) affect protective efficacy in mice, showing that domain combinations significantly influence immunogenicity and protection.

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

A Novel Swine Model of the Acute Respiratory Distress Syndrome Using Clinically-Relevant Injury Exposures

This paper develops a swine model of ARDS using clinically relevant injury exposures and shows it recapitulates human ARDS features.

Balancing the influenza neuraminidase and hemagglutinin responses by exchanging the vaccine virus backbone

The paper shows that exchanging viral backbone genes can increase neuraminidase content in influenza virions, leading to better NA antibody responses in mice.

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

N-linked glycan sites on the influenza NA head domain are required for efficient IAV incorporation and replication

This study shows that N-linked glycan sites on the influenza NA head domain are essential for efficient virion incorporation and replication, with differences in glycan conservation between H1N1 and H3N2 IAVs.