Author

R. Xiang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

X. Wang· 3 shared J. Shi· 2 shared J. Wu· 2 shared L. Chen· 2 shared W. Wu· 2 shared A. Chen· 1 shared C. Sun· 1 shared D. Chen· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

X. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

Y. Ou, M. Liu, K. Zhan, W. Wu, J. Huang, H. Sun, H. Zheng, X. Yu, H. Gong, Z. Han, A. Chen, Y. Liao, Y. Lin, G. Liu, Q. Liu, , S. Zhong

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

bioRxiv · Oct 12, 2022 · PreprintImmunology

A systematic CRISPR screen reveals an IL-20/IL20RA-mediated peritoneal immune crosstalk to prevent the ovarian cancer metastasis

J. Li, X. Qin, J. Shi, X. Wang, T. Li, M. Xu, X. Chen, Y. Zhao, J. Han, Y. Piao, W. Zhang, P. Qu, L. Wang, R. Xiang, Y. Shi

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

eLife · Jun 11, 2021Peer-reviewedCancer Biology

B.1.1.7 and B.1.351 variants are highly virulent in K18-ACE2 transgenic mice and show different pathogenic patterns from early SARS-CoV-2 strains

P. Radvak, H. J. Kwon, M. Kosikova, U. Ortega-Rodriguez, R. Xiang, J.-N. Phue, R.-F. Shen, J. Rozzelle, N. Kapoor, T. Rabara, J. Fairman, H. Xie

This study shows that B.1.1.7 and B.1.351 SARS-CoV-2 variants are more lethal than early strains in K18-hACE2 mice and cause distinct pathogenic effects.

bioRxiv · Jun 5, 2021Immunology

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

D. Chen, J. Sun, J. Zhu, X. Ding, T. Lan, L. Zhu, R. Xiang, P. Ding, H. Wang, X. Wang, W. Wu, J. Qiu, S. Wang, H. Li, F. An, , X. Xu

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

bioRxiv · Jun 13, 2020 · PreprintCell Biology