De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness
J. Koh, Y. D. Woo, H. J. Yoo, J.-P. Choi, S. H. Kim, Y.-S. Chang, K. C. Jung, J. H. Kim, Y. K. Jeon, H. Y. Kim, D. H. Chung
This study shows that de novo fatty-acid synthesis via ACC1 prevents iNKT cell death and promotes their pathogenic roles in allergic asthma.
bioRxiv · Feb 15, 2023 · PreprintImmunology