Author

J.-P. Gorvel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:proteomics· 1

Frequent Co-Authors

S. P. Salcedo· 3 shared A. Louche· 2 shared F. Lembo· 2 shared J.-P. Borg· 2 shared T. L. Lacerda· 2 shared A. Blanco· 1 shared A. Keriel· 1 shared C. Berge· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

S. P. Salcedo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SLAMF7 and SLAMF8 receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria

J. M. Pellegrini, A. Keriel, L. Gorvel, S. Hanniffy, V. Arce-Gorvel, M. Bosilkovski, J. Solera, S. Meresse, S. MEMET, J.-P. Gorvel

This study identifies SLAMF7 and SLAMF8 as key regulators of human pDC responses to intracellular bacteria, showing their role in modulating type I IFN production and mitochondrial ROS levels.

bioRxiv · Apr 25, 2024Immunology

The unique Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins

A. Louche, A. Blanco, T. L. Lacerda, C. Lionnet, C. Berge, M. Rolando, F. Lembo, J.-P. Borg, C. Buchrieser, M. Nagahama, J.-P. Gorvel, V. Gueguen-Chaignon, L. Terradot, S. P. Salcedo

This study shows that Brucella effectors NyxA and NyxB target SENP3 to alter nucleolar protein localization, promoting bacterial replication.

bioRxiv · Apr 23, 2021 · PreprintMicrobiology

The TIR-domain containing effectors BtpA and BtpB from Brucella abortus block energy metabolism

J. M. Coronas-Serna, A. Louche, M. Rodriguez-Escudero, M. Roussin, P. R. Imbert, I. Rodriguez-Escudero, M. Molina, J.-P. Gorvel, V. J. Cid, S. P. Salcedo

This study shows BtpA and BtpB from Brucella abortus reduce host cell NAD+ levels by acting as NAD+ hydrolases, impairing energy metabolism and immune responses.

bioRxiv · Jul 15, 2019Microbiology

Brucella effector hijacks endoplasmic reticulum quality control machinery to prevent premature egress

J.-B. Luizet, J. Raymond, T. L. Lacerda, M. Bonici, F. Lembo, K. Willemart, J.-P. Borg, J.-P. Gorvel, S. P. Salcedo

This study identifies BspL, a Brucella effector that modulates ERQC to control autophagic vacuole formation and prevent bacterial premature egress.

bioRxiv · Jul 11, 2019 · PreprintMicrobiology