The TIR-domain containing effectors BtpA and BtpB from Brucella abortus block energy metabolism
J. M. Coronas-Serna, A. Louche, M. Rodriguez-Escudero, M. Roussin, P. R. Imbert, I. Rodriguez-Escudero, M. Molina, J.-P. Gorvel, V. J. Cid, S. P. Salcedo
This study shows BtpA and BtpB from Brucella abortus reduce host cell NAD+ levels by acting as NAD+ hydrolases, impairing energy metabolism and immune responses.
bioRxiv · Jul 15, 2019Microbiology