Unique unfoldase/aggregase activity of a molecular chaperone that dysregulates a translational elongation factor
K.-S. Jo, J.-H. Kim, K.-S. Ryu, Y.-H. Lee, C.-Y. Wang, J.-S. Kang, Y.-S. Lee, M.-D. Seo, H.-S. Won
This study shows Hsp33's non-canonical unfoldase/aggregase activity causes EF-Tu aggregation and degradation under heat stress, impacting cell survival.
bioRxiv · Dec 10, 2018 · PreprintBiochemistry