Author

J.-Y. Dube

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

F. McIntosh· 3 shared M. A. Behr· 3 shared A. J. Minnaard· 1 shared B. Moody· 1 shared C. Aagaard· 1 shared D. Houle· 1 shared G. Jungersen· 1 shared H. Strand Clemmensen· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

F. McIntosh

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3 papers

Recent·Most cited

In vivo antigen expression regulates CD4 T cell differentiation and vaccine efficacy against Mycobacterium tuberculosis infection

H. Strand Clemmensen, J.-Y. Dube, F. McIntosh, I. Rosenkrands, G. Jungersen, C. Aagaard, P. Andersen, M. A. Behr, R. Mortensen

This study shows that high in vivo antigen expression drives CD4 T cell differentiation and reduces vaccine efficacy against Mtb, while vaccination with adjuvanted antigens can maintain T cells in a less-differentiated, protective state.

bioRxiv · Feb 2, 2021Immunology

Heterologous production of 1-tuberculosinyladenosine in Mycobacterium kansasii models pathoevolution towards the transcellular lifestyle of Mycobacterium tuberculosis.

M. Ghanem, J.-Y. Dube, J. Wang, F. McIntosh, D. Houle, P. Domenech, M. B. Reed, S. Raman, J. Buter, A. J. Minnaard, B. Moody, M. A. Behr

This study introduces the M. tuberculosis-specific gene pair into M. kansasii to model pathoevolution, finding that 1-TbAd production enhances early infection but impairs long-term survival.

bioRxiv · Apr 25, 2020Microbiology

Synthetic mycobacterial molecular patterns partially complete Freund's adjuvant

J.-Y. Dube, F. McIntosh, J. G. Zarruk, S. David, J. Nigou, M. A. Behr

This study identifies synthetic mycobacterial molecular patterns that replicate the adjuvant effect of CFA, offering a defined alternative for immunological research and vaccine development.

bioRxiv · Jan 23, 2020Immunology