Author

M. A. Behr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Assay:proteomics· 4 Approach:statistical model· 4 Research Focus:drug response / drug discovery· 2 Research Focus:phylogenetics / evolution· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

F. McIntosh· 3 shared J.-Y. Dube· 3 shared A. Lupien· 2 shared J. R. Sullivan· 2 shared V. Kapur· 2 shared A. Dippenaar· 1 shared A. J. Minnaard· 1 shared B. Moody· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersImmunology

F. McIntosh

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

An imputed ancestral reference genome for the Mycobacterium tuberculosis complex better captures structural genomic diversity for reference-based alignment workflows

L. B. Harrison, V. Kapur, M. A. Behr

The paper introduces an imputed ancestral reference genome (MTBC0) for the Mycobacterium tuberculosis complex that improves read mapping and SNP calling compared to existing references.

bioRxiv · Sep 7, 2023 · PreprintMicrobiology

Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

J. R. Sullivan, J. Yao, C. Courtine, A. Lupien, J. Herrmann, R. Müller, M. A. Behr

bioRxiv · Jun 27, 2022Microbiology

Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

J. R. Sullivan, A. Lupien, E. Kalthoff, C. Hamela, L. Taylor, K. A. Munro, T. M. Schmeing, L. Kremer, M. A. Behr

The paper shows that combining epetraborole with norvaline enhances efficacy against Mycobacterium abscessus in a murine model.

bioRxiv · Jun 1, 2021Microbiology

In vivo antigen expression regulates CD4 T cell differentiation and vaccine efficacy against Mycobacterium tuberculosis infection

H. Strand Clemmensen, J.-Y. Dube, F. McIntosh, I. Rosenkrands, G. Jungersen, C. Aagaard, P. Andersen, M. A. Behr, R. Mortensen

This study shows that high in vivo antigen expression drives CD4 T cell differentiation and reduces vaccine efficacy against Mtb, while vaccination with adjuvanted antigens can maintain T cells in a less-differentiated, protective state.

bioRxiv · Feb 2, 2021Immunology

Heterologous production of 1-tuberculosinyladenosine in Mycobacterium kansasii models pathoevolution towards the transcellular lifestyle of Mycobacterium tuberculosis.

M. Ghanem, J.-Y. Dube, J. Wang, F. McIntosh, D. Houle, P. Domenech, M. B. Reed, S. Raman, J. Buter, A. J. Minnaard, B. Moody, M. A. Behr

This study introduces the M. tuberculosis-specific gene pair into M. kansasii to model pathoevolution, finding that 1-TbAd production enhances early infection but impairs long-term survival.

bioRxiv · Apr 25, 2020Microbiology

Synthetic mycobacterial molecular patterns partially complete Freund's adjuvant

J.-Y. Dube, F. McIntosh, J. G. Zarruk, S. David, J. Nigou, M. A. Behr

This study identifies synthetic mycobacterial molecular patterns that replicate the adjuvant effect of CFA, offering a defined alternative for immunological research and vaccine development.

bioRxiv · Jan 23, 2020Immunology

Zoonotic tuberculosis in India: looking beyond Mycobacterium bovis

S. C. Duffy, S. Srinivasan, M. A. Schilling, T. Stuber, S. N. Danchuk, J. S. Michael, M. Venkatesan, N. Bansal, S. Maan, N. Jindal, D. Chaudhary, P. Dandapat, R. Katani, S. Chothe, M. Veerasami, , M. A. Behr

This study investigates zoonotic tuberculosis in India by analyzing human and cattle Mycobacterium tuberculosis complex isolates, finding no M. bovis in humans and highlighting the presence of M. orygis and M. tuberculosis in both species.

bioRxiv · Nov 20, 2019 · PreprintMicrobiology

A New Phylogenetic Framework for the Animal-adapted Mycobacterium tuberculosis Complex

D. Brites, C. Loiseau, F. Menardo, S. Borrell, M. B. Boniotti, R. Warren, A. Dippenaar, S. D. C. Parsons, C. Beisel, M. A. Behr, J. A. Fyfe, M. Coscolla, S. Gagneux

This study analyzes 529 MTBC genomes to reveal the phylogenetic relationships and evolutionary history of animal-adapted MTBC ecotypes, identifying four clades and suggesting host shifts and demographic factors drive host tropism.

bioRxiv · Aug 3, 2018Evolutionary Biology

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

L. S. Ates, F. Sayes, W. Frigui, R. Ummels, M. P. M. Damen, D. Bottai, M. A. Behr, W. Bitter, L. Majlessi, R. Brosch

This study shows that BCG vaccine strains lack PE_PGRS/PPE-MPTR export due to RD5 inactivation, reducing antigenic repertoire but not vaccine efficacy.

bioRxiv · Feb 14, 2018Microbiology