A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease
The International Genomics of Alzheimer's Project, Kuan-lin Huang, The Alzheimer's Disease Neuroimaging Initiative, Edoardo M. Marcora, Anna A. Pimenova, Antonio Fabio Di Narzo, Manav Kapoor, Sheng Chih Jin, Oscar Harari, Sarah E. Bertelsen, Benjamin Peter Fairfax, Jacek Czajkowski, Vincent Antoine Chouraki, Benjamin Grenier‐Boley, Céline Bellenguez, , Alison Goate
This study identifies a haplotype lowering PU.1 expression in myeloid cells that delays Alzheimer’s disease onset by affecting gene expression and function.
Nature Neuroscience · Jun 19, 2017Peer-reviewedNeuroscience