Andrew Thomas McKenzie

The paper compares fixation and cryopreservation methods for brain preservation, finding that ASC with SDS permeabilization matches aldehyde perfusion in preserving tissue structure.

This study compares how different perfusate compositions affect rat brain preservation, finding minimal impact on light microscopy outcomes despite changes in osmotic additives and vascular clearance.

This review assesses the duration of cerebral perfusion after global ischemia, finding a gradual decline rather than a sharp threshold, with variability across studies.

This paper shows that macroscopic and radiological perfusion metrics do not reliably predict ultrastructural preservation in brain tissue after hyperosmotic perfusion.

The paper describes methods for establishing a canine brain bank and presents preliminary findings on brain aging using lipofuscin burden analysis.

This paper presents a protocol for preserving fixed whole brains using aldehyde-based cryopreservation, showing preserved cellular architecture after long-term storage.

The paper evaluates ultrastructural preservation quality in postmortem brain tissue using EM and light microscopy to identify artifacts and assess their impact on research applications.

The paper identifies Zfp189 as a key driver of a transcriptional network promoting stress resilience in prefrontal cortex neurons through CREB regulation.

This study identifies a haplotype lowering PU.1 expression in myeloid cells that delays Alzheimer’s disease onset by affecting gene expression and function.