Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs with Trisomy 21
Jenny A. Klein, Zhen Li, Sanjeev Rampam, Jack Cardini, Amara Ayoub, Patricia R. Shaw, Angela L. Rachubinski, Joaquin Maximiliano Espinosa, Ella Zeldich, Tarik F. Haydar
The paper shows that modulating the Sonic Hedgehog pathway in trisomic NPCs rescues gene expression dysregulation associated with Down syndrome.
Frontiers in Cellular Neuroscience · Jan 4, 2022Peer-reviewedNeuroscience