Ella Zeldich

Trisomy 21 Perturbs Oligodendrocyte Developmental States and Oligo-Neuron Communication in Human Forebrain Assembloids

This study investigates how trisomy 21 affects oligodendrocyte development and neuron-glia communication in human forebrain assembloids, finding a shift toward a pre-myelinating state and disrupted myelination.

Flexible 3D multimodal organoid interface reveals functional subnetworks and coordinated circuit activity in cortical organoids

This paper introduces INFORM, a multimodal interface for cortical organoids that enables long-term recordings and modulation of neural activity, revealing functional subnetworks and inhibitory signaling.

Seeing clearly with CLARI-O: a window into cellular architecture, interactions, and morphology of organoid models.

This paper introduces CLARI-O, a tissue-clearing technique for 3D visualization of cortical organoids and assembloids, enabling structural and functional analysis of cellular interactions and integration in vitro and in vivo.

A pipeline for cell migration analysis in live-cell imaging data from human iPSC-derived forebrain assembloids.

Stage-specific exposure to an activity-permissive media enhances neuronal maturation in oligodendrocyte-enriched cortical organoids

This study shows that exposing oligodendrocyte-enriched cortical organoids to a specific medium during development enhances neuronal activity and maturation while preserving oligodendrocyte development.

High-Field Multinuclear MRI Reveals Sodium Relaxation Heterogeneity in Cortical Organoids

This study uses high-field multinuclear MRI to analyze sodium relaxation heterogeneity in cortical organoids, revealing distinct relaxation components and spatial microenvironment variations.

Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices

The paper identifies muscarinic receptor subtypes in primate prefrontal and cingulate cortices, revealing regional differences in receptor expression and functional properties.

A neurorecording toolkit for longitudinal assessments of transplanted human cortical organoids in vivo

This paper presents a neurorecording toolkit to longitudinally assess transplanted human cortical organoids in vivo, showing increased neuronal activity and synchronicity over time.

IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

Mesenchymal Cell-Derived Extracellular Vesicles Ameliorate Age-Related Deficits in Working Memory as well as Brain MRI and CSF in vivo Biomarkers of Neurodegeneration in Rhesus Monkeys.

This study shows that MSC-EVs improve cognitive function and reduce neurodegeneration biomarkers in aged rhesus monkeys.

AutoMorFi: Automated Whole-image Morphometry in Fiji/ImageJ for Diverse Analyses and Discoveries

AutoMorFi automates whole-image morphometric analysis, generating over 47 measurements per cell quickly and enabling new discoveries across diverse biological samples.

Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome

This study uses isogenic cortical spheroids and scRNA-seq to identify transcriptomic changes in trisomic cells, revealing developmental asynchrony in excitatory neurons in Down syndrome.

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs with Trisomy 21

The paper shows that modulating the Sonic Hedgehog pathway in trisomic NPCs rescues gene expression dysregulation associated with Down syndrome.