Zhen Li

A humanized mouse model system mimics prenatal Zika infection and reveals premature differentiation

This paper develops a humanized mouse model of prenatal Zika infection and shows it mimics human phenotypes, including disrupted neural stem cells and brain injuries.

MuMu: a sample multiplexing protocol for droplet-based simultaneous single nuclei RNA- and ATAC-seq systems

The paper introduces a sample multiplexing protocol for simultaneous single nuclei RNA-seq and ATAC-seq, reducing cost and technical batch effects.

Comprehensive multiomic profiling of somatic mutations in malformations of cortical development

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome

This study uses isogenic cortical spheroids and scRNA-seq to identify transcriptomic changes in trisomic cells, revealing developmental asynchrony in excitatory neurons in Down syndrome.

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs with Trisomy 21

The paper shows that modulating the Sonic Hedgehog pathway in trisomic NPCs rescues gene expression dysregulation associated with Down syndrome.

Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex

The paper uses whole-genome and RNA sequencing from the human prefrontal cortex to identify genetic variants and transcriptomic changes associated with neurodevelopment and neuropsychiatric disorders.