NeuroscienceFrontiers in NeurosciencePeer-reviewed
Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome
Zhen Li, Jenny A. Klein, Sanjeev Rampam…·Ella Zeldich
This study uses isogenic cortical spheroids and scRNA-seq to identify transcriptomic changes in trisomic cells, revealing developmental asynchrony in excitatory neurons in Down syndrome.