Author

Jenny A. Klein

Broad InstituteORCID 0000-0002-2255-2258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Anna J. Nathanson· 3 shared Lindy E. BarrettiD· 3 shared Darina TrendafilovaiD· 2 shared Ella ZeldichiD· 2 shared Lee L. RubiniD· 2 shared Martin H. BerryeriD· 2 shared Sanjeev RampamiD· 2 shared Tarik F. HaydariD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Anna J. Nathanson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21

Jenny A. Klein, Suraj Upadhya, Anna J. Nathanson, Dana Silvian, Eric F. Zaniewski, Robert Morris, Wilhelm Haas, Lindy E. Barrett

This study identifies aberrant chromatin remodeling in Trisomy 21 NPCs that impairs neurogenesis and shows that PRC2 inhibition can partially restore neurogenic potential.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells

Martin H. Berryer, Matthew Tegtmeyer, Loïc Binan, Vera Valakh, Anna J. Nathanson, Darina Trendafilova, Ethan Crouse, Jenny A. Klein, Daniel Meyer, Olli P. H. Pietiläinen, Francesca A. Rapino, Samouil L. Farhi, Lee L. Rubin, Steven A. McCarroll, Ralda Nehme, Lindy E. Barrett

This study develops a rapid, scalable method to generate functional human astrocytes from pluripotent stem cells using NGN2 induction, showing high homogeneity and disease relevance.

iScience · May 30, 2023Peer-reviewedNeuroscience

An automated high-content synaptic phenotyping platform in human neurons and astrocytes reveals a role for BET proteins in synapse assembly

Martin H. Berryer, Gizem Rizki, Anna J. Nathanson, Jenny A. Klein, Darina Trendafilova, Sara G. Susco, Daisy Lam, Angelica Messana, Kristina M. Holton, Kyle W. Karhohs, Beth A. Cimini, Kathleen Lindahl Pfaff, Anne Elizabeth Carpenter, Lee L. Rubin, Lindy E. Barrett

The paper develops an automated high-content synaptic phenotyping platform in human neurons and astrocytes, identifying BET inhibitors as key regulators of synapse assembly.

eLife · Apr 12, 2023Peer-reviewedNeuroscience

Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome

Zhen Li, Jenny A. Klein, Sanjeev Rampam, Ronni Kurzion, Natalie Baker Campbell, Yesha Patel, Tarik F. Haydar, Ella Zeldich

This study uses isogenic cortical spheroids and scRNA-seq to identify transcriptomic changes in trisomic cells, revealing developmental asynchrony in excitatory neurons in Down syndrome.

Frontiers in Neuroscience · Sep 7, 2022Peer-reviewedNeuroscience

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs with Trisomy 21

Jenny A. Klein, Zhen Li, Sanjeev Rampam, Jack Cardini, Amara Ayoub, Patricia R. Shaw, Angela L. Rachubinski, Joaquin Maximiliano Espinosa, Ella Zeldich, Tarik F. Haydar

The paper shows that modulating the Sonic Hedgehog pathway in trisomic NPCs rescues gene expression dysregulation associated with Down syndrome.

Frontiers in Cellular Neuroscience · Jan 4, 2022Peer-reviewedNeuroscience