Structural and Mechanistic Basis of F227C-Mediated Hypersusceptibility to Islatravir in HIV-1 Reverse Transcriptase
Alexa A. Snyder, Isabella L. Kaufman, Jack MacQuillan, Ryan L. Slack, Karen A. Kirby, Eleftherios Michailidis, Stefan G. Sarafianos
The paper investigates how the F227C mutation in HIV-1 reverse transcriptase increases susceptibility to islatravir, revealing structural and mechanistic insights into this collateral sensitivity.
bioRxiv · Jun 12, 2026 · PreprintBiochemistry