Ryan L. Slack

The paper investigates how the F227C mutation in HIV-1 reverse transcriptase increases susceptibility to islatravir, revealing structural and mechanistic insights into this collateral sensitivity.

This paper investigates how HIV capsid core translocates through the Nuclear Pore Complex by analyzing FG repeat interactions and identifies an affinity gradient that facilitates unidirectional translocation.

This paper optimizes Bio-Layer Interferometry (BLI) protocols to measure binding affinities of antiviral compounds with viral proteins, demonstrating sub-nanomolar KD values and covalent interactions.