Activation of KCC2 during development alleviates cognitive, behavioral, and neural excitability in adult CDKL5-deficient mice
Muhammad Nauman Arshad, Christopher E. Bope, Jacob S. Dengler, Shu Fun Josephine Ng, Joshua L. Smalley, Toshiya Nishi, Zhong Zhong, Stephen J. Moss, Paul A Davies
This study shows that activating KCC2 during development reduces seizures, cognitive, and behavioral issues in adult CDKL5-deficient mice, but adult treatment is less effective.
bioRxiv · Feb 26, 2025 · PreprintNeuroscience