Author

Christopher E. Bope

Tufts University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Joshua L. SmalleyiD· 4 shared Paul A DaviesiD· 4 shared Stephen J. MossiD· 4 shared Catherine ChoiiD· 3 shared Georgina KontouiD· 3 shared Miguel A. Rodriguez Santos· 3 shared Nicholas J. BrandoniD· 3 shared Qiu Ren· 3 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Joshua L. SmalleyORCID

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4 papers

Recent·Most cited

Activation of KCC2 during development alleviates cognitive, behavioral, and neural excitability in adult CDKL5-deficient mice

Muhammad Nauman Arshad, Christopher E. Bope, Jacob S. Dengler, Shu Fun Josephine Ng, Joshua L. Smalley, Toshiya Nishi, Zhong Zhong, Stephen J. Moss, Paul A Davies

This study shows that activating KCC2 during development reduces seizures, cognitive, and behavioral issues in adult CDKL5-deficient mice, but adult treatment is less effective.

bioRxiv · Feb 26, 2025 · PreprintNeuroscience

KCC2 is required for the survival of mature neurons but not for their development

Georgina Kontou, Josephine Ng, Ross A. Cardarelli, Jack H. Howden, Catherine Choi, Qiu Ren, Miguel A. Rodriguez Santos, Christopher E. Bope, Jake S. Dengler, Matt R. Kelley, Paul A Davies, Josef T. Kittler, Nicholas J. Brandon, Stephen J. Moss, Joshua L. Smalley

This study shows that KCC2 is essential for the survival of mature neurons but not for their development or structural formation.

Journal of Biological Chemistry · Jan 1, 2021Peer-reviewedNeuroscience

Isolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes

Joshua L. Smalley, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Paul A Davies, Nicholas J. Brandon, Stephen J. Moss

This study isolates and characterizes multi-protein complexes containing Kcc2 from brain plasma membranes, identifying novel interactors and phosphorylation sites that may regulate its function.

Frontiers in Molecular Neuroscience · Oct 22, 2020Peer-reviewedNeuroscience

The K-Cl co-transporter 2 is a point of convergence for multiple autism spectrum disorder and epilepsy risk gene products.

The paper identifies KCC2 as a convergence point for ASD/Epi risk genes through proteomic analysis and shows its interaction with FMRP targets and effects on GABAergic inhibition.

bioRxiv · Mar 2, 2020 · PreprintNeuroscience