Author

Toshiya Nishi

Ovid Therapeutics (United States)ORCID 0000-0002-9451-2423Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1

Frequent Co-Authors

Joshua L. SmalleyiD· 2 shared Muhammad Nauman ArshadiD· 2 shared Paul A DaviesiD· 2 shared Stephen J. MossiD· 2 shared Zhong Zhong· 2 shared Christopher E. Bope· 1 shared Jacob S. Dengler· 1 shared Josephine NgiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Joshua L. SmalleyORCID

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2 papers

Recent·Most cited

KCC2 Activation Reverses Neurophysiological and Behavioral Deficits in Female Rett Mice

Muhammad Nauman Arshad, Josephine Ng, Seda Salar, Krithika Abiraman, Toshiya Nishi, Zhong Zhong, Joshua L. Smalley, Paul A Davies, Stephen J. Moss

This study shows that activating KCC2 improves neurophysiological and behavioral symptoms in female Rett syndrome mice.

bioRxiv · Jan 14, 2026 · PreprintNeuroscience

Activation of KCC2 during development alleviates cognitive, behavioral, and neural excitability in adult CDKL5-deficient mice

Muhammad Nauman Arshad, Christopher E. Bope, Jacob S. Dengler, Shu Fun Josephine Ng, Joshua L. Smalley, Toshiya Nishi, Zhong Zhong, Stephen J. Moss, Paul A Davies

This study shows that activating KCC2 during development reduces seizures, cognitive, and behavioral issues in adult CDKL5-deficient mice, but adult treatment is less effective.

bioRxiv · Feb 26, 2025 · PreprintNeuroscience