Diet induced insulin resistance is due to induction of PTEN expression
Radha Mukherjee, Priya Pancholi, Malvika Sharma, Hilla Solomon, Merna N. Timaul, Claire N. Thant, Rory Mcgriskin, Omar Hayatt, Vladimir Markov, John D’Allara, Simona Bekker, Jacqueline Candelier, Sebastian E. Carrasco, Elisa de Stanchina, Kiran Gireesan Vanaja, Neal X. Rosen
The paper shows that diet-induced insulin resistance results from increased PTEN expression, which inhibits PI3K signaling, and that PTEN and mTORC1 inhibitors can reverse this effect.
bioRxiv · Mar 25, 2025 · PreprintCell Biology