Sebastian E. Carrasco

De novo lipogenesis controls antigen presentation and metastatic immune escape in triple-negative breast cancer.

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses

This study shows that colorectal cancers with different metastatic potential trigger distinct early T cell responses, with non-metastatic tumors inducing cytotoxic T cells and pro-metastatic tumors causing hypoactivated T cells.

Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer

This study identifies persistent interferon signaling and clonal expansion as early events in NDMA-induced liver cancer by analyzing molecular changes in mice.

Chlamydia muridarum Infection Impacts Murine Models of Intestinal Inflammation and Cancer

This study shows that Chlamydia muridarum infection affects different models of intestinal inflammation and cancer in mice, with varying outcomes depending on the model.

Diet induced insulin resistance is due to induction of PTEN expression

The paper shows that diet-induced insulin resistance results from increased PTEN expression, which inhibits PI3K signaling, and that PTEN and mTORC1 inhibitors can reverse this effect.

Assessing the Biosecurity Risk of Footwear as a Fomite for Transmission of Adventitious Infectious Agents to Mice

This study assesses the biosecurity risk of footwear as a fomite for transmitting infectious agents to mice, finding that shoe debris and contact media did not cause illness in mice despite containing non-enzootic agents.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Chlamydia muridarum Causes Persistent Subclinical Infection and Elicits Innate and Adaptive Immune Responses in C57BL/6J, BALB/cJ and J:ARC(S) Mice Following Exposure to Shedding Mice

This study shows that C57BL/6J, BALB/cJ, and J:ARC(S) mice develop persistent subclinical Chlamydia muridarum infections with immune responses, suggesting the need to exclude Cm from mouse colonies used in GI disease research.

Assessment of Antimicrobial Therapy in Eradicating Chlamydia muridarum in Research Mice: Immune Status and its Impact on Outcomes

This study evaluates antibiotic efficacy against Chlamydia muridarum in mice, finding that immunocompetent mice can be cleared with TMS, while immunodeficient mice remain infected.