Membrane Permeability Drives the Extreme Potency of Fentanyl but not Isotonitazene
Joseph Clayton, George J. Farmer, Jacqueline R. Glenn, Shailesh N. Mistry, J. Robert Lane, Lei Shi, Lidiya Stavitskaya, Meritxell Canals, Jana Shen
This study investigates how membrane permeability affects the potency of fentanyl and isotonitazene, finding that fentanyl's extreme potency may be due to its ability to accumulate in membranes and repartition to bind receptors.
bioRxiv · Jul 22, 2025 · PreprintBiophysics