Author

Shailesh N. Mistry

University of NottinghamORCID 0000-0002-2252-1689Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew B. TobiniD· 1 shared Andrew R. BottrilliD· 1 shared Arthur ChristopoulosiD· 1 shared Colin MolloyiD· 1 shared Craig W. LindsleyiD· 1 shared Elham KhajehaliiD· 1 shared George J. Farmer· 1 shared J. Robert LaneiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Andrew B. TobinORCID

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2 papers

Recent·Most cited

Membrane Permeability Drives the Extreme Potency of Fentanyl but not Isotonitazene

Joseph Clayton, George J. Farmer, Jacqueline R. Glenn, Shailesh N. Mistry, J. Robert Lane, Lei Shi, Lidiya Stavitskaya, Meritxell Canals, Jana Shen

This study investigates how membrane permeability affects the potency of fentanyl and isotonitazene, finding that fentanyl's extreme potency may be due to its ability to accumulate in membranes and repartition to bind receptors.

bioRxiv · Jul 22, 2025 · PreprintBiophysics

Activation of M1 muscarinic receptors reduce pathology and slow progression of neurodegenerative disease.

Louis Dwomoh, Mario Rossi, Miriam Scarpa, Elham Khajehali, Colin Molloy, Pawel Herzyk, Shailesh N. Mistry, Andrew R. Bottrill, Patrick Michael Sexton, Arthur Christopoulos, Peter Jeffrey Conn, Craig W. Lindsley, Sophie J. Bradley, Andrew B. Tobin

This study shows that activating M1 muscarinic receptors with VU846 slows murine prion disease progression, reduces neuroinflammation, and preserves synaptic proteins.

bioRxiv · Jul 30, 2021 · PreprintNeuroscience