Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking.
Andrew R. Gomez, Hyae Ran Byun, Shaogen Wu, AKM Ghulam Muhammad, Jasmine Ikbariyeh, Jaelin Chen, Alek Muro, Lin Li, Kenneth E. Bernstein, Richard I. Ainsworth, Warren G. Tourtellotte
This study shows that ACE expression in microglia reduces amyloid β deposition and neurodegeneration by enhancing SYK signaling and endolysosomal trafficking in Alzheimer's disease models.
bioRxiv · Apr 24, 2024 · PreprintNeuroscience