Kenneth E. Bernstein

This study identifies the N-terminal catalytic domain of ACE as the primary site for endogenous opioid peptide degradation in brain tissue and shows that inhibiting this domain reduces opioid degradation.

This study shows that ACE expression in microglia reduces amyloid β deposition and neurodegeneration by enhancing SYK signaling and endolysosomal trafficking in Alzheimer's disease models.