Richard I. Ainsworth

Mitochondrial instability contributes to IFN-driven heart disease.

This study shows chronic IFN exposure impairs heart function by causing mitochondrial stress, mtDNA release, and a self-sustaining inflammatory loop in cardiomyocytes.

Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways

This study shows that loss of TRIM21 increases UVB-induced systemic inflammation by enhancing IFN expression through impaired STING signaling in mice.

A CD57+ cytotoxic CD8 T cell subset associated with fibrotic lung disease in systemic sclerosis

The paper identifies a CD57+ cytotoxic CD8 T cell subset expanded in SSc-ILD patients and links it to lung injury through CD155-CD226 interactions.

Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking.

This study shows that ACE expression in microglia reduces amyloid β deposition and neurodegeneration by enhancing SYK signaling and endolysosomal trafficking in Alzheimer's disease models.

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.