Ectopic transcription due to inappropriately inherited histone methylation may interfere with the ongoing function of terminally differentiated cells
Juan D. Rodriguez, Monica N. Reeves, Hsiao‐Lin V. Wang, Jaely Z. Chavez, Rhea Rastogi, Sindy R. Chavez, Elicia A. Preston, Madhav S. Chadha, Li‐Yang Sun, Emily J. Hill, Victor G. Corces, Karen L. Schmeichel, John I. Murray, David J. Katz
The paper shows that mutations in histone modifying enzymes cause ectopic gene expression in adult worms, leading to behavioral defects that may be reversible.
bioRxiv · Oct 29, 2023 · PreprintDevelopmental Biology