Elicia A. Preston

This study investigates the distinct roles of TBX-35 and CEH-51 in C. elegans mesoderm lineage development using genetic and single-cell RNA sequencing approaches.

The paper shows that mutations in histone modifying enzymes cause ectopic gene expression in adult worms, leading to behavioral defects that may be reversible.

The paper identifies transcription factors that regulate anterior gene expression in C. elegans embryos through cis-regulatory elements and enhancer analysis.

The paper identifies regulatory mechanisms for posterior Hox genes nob-1 and php-3 in C. elegans, showing that anterior Hox gene ceh-13 and other factors activate these genes, influencing cell lineage and position.

The paper maps lineage and transcriptome relationships in C. elegans embryogenesis using single-cell transcriptomics, revealing lineage-transcriptome correlation breakdown in late divisions.