Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li‐Kai Lin, Sonal Padalkar, George P. McCabe, Lia Stanciu, Yuri L. Lyubchenko, Deniz Kirik, J. C. Rochet
The paper compares neurotoxicity of human A53T and mouse α-synuclein variants, finding mouse aSyn is less toxic due to C-terminal substitutions reducing membrane-induced aggregation and vesicle permeabilization.
Molecular Neurodegeneration · Sep 8, 2020Peer-reviewedNeuroscience