Disruption of Tonic Endocannabinoid Signaling Triggers the Generation of a Stress Response
Gavin N. Petrie, Georgia Balsevich, Tamás Füzesi, Robert J. Aukema, Wouter P. F. Driever, Mario van der Stelt, Jaideep S. Bainsand, Matthew N. Hill
The paper shows that disrupting tonic endocannabinoid signaling increases HPA axis activation by enhancing CRH neuron activity in the PVN, leading to stress-like behaviors and elevated corticosterone.
bioRxiv · Sep 27, 2022 · PreprintNeuroscience