Mario van der Stelt

This study shows acetaminophen reduces pain by altering lipid signaling via cannabinoid receptors and enzymes in mice.

The paper quantifies physiological fatty acid uptake in vivo and shows that nutrient accessibility differs from uptake capacity, shaped by tissue architecture and systemic constraints.

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

This study develops clickable fatty acids to quantify single-cell uptake by immune cells, finding polyunsaturated fatty acids are preferentially taken up by various immune cell types.

The paper identifies reduced triacylglycerols and lipid droplets in resilient Alzheimer's donors compared to AD patients, using multi-omics analysis of brain tissue.

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

The paper introduces fluorescent activity-based probes to map MAGL activity in brain tissues, revealing its spatial distribution in mouse and human brains.

CellEKT profiles cellular target engagement of kinase inhibitors using chemical proteomics to determine IC50 values across over 300 kinases and validate results with phosphoproteomics and NanoBRET.

The paper proposes an on-demand release model for endocannabinoid 2-AG via microvesicles, showing stimulus-dependent release regulated by PKC, DAGL, and Arf6.

The paper shows that two endocannabinoids, 2-AG and AEA, signal to different cell types (neurons and astrocytes), inducing distinct synaptic regulation mechanisms.

The paper shows that disrupting tonic endocannabinoid signaling increases HPA axis activation by enhancing CRH neuron activity in the PVN, leading to stress-like behaviors and elevated corticosterone.