Tamás Füzesi

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.

This study identifies recurrent inhibition as a key circuit motif regulating functional states of stress effector neurons through experimental and computational approaches.

A transient hypothalamic CRH signal coordinates social investigation in mice

This study identifies a transient CRH signal in hypothalamic neurons that coordinates social investigation in mice by modulating behavior during social encounters.

Exercise Leverages a Post-Stress Therapeutic Window in Hypothalamic CRH Neurons to Enable Recovery from Threat Sensitization

The paper shows exercise alleviates acute stress through a time-sensitive mechanism involving CRH neurons and interactions between glucocorticoids and BDNF.

Psilocybin induces sex- and context-specific recruitment of the stress axis

This study shows psilocybin activates hypothalamic stress-related neurons, with stronger effects in female mice and context-dependent changes in threat assessment.

Hypothalamic CRH neurons gate rapid social appraisal of conspecifics

This study identifies CRH neurons in the hypothalamus as critical for rapid social appraisal, showing their activity scales with social context and persists despite behavioural habituation.

Contralesional hippocampal spreading depolarization promotes functional recovery after stroke

This study shows that contralesional hippocampal spreading depolarization improves functional recovery after hippocampal stroke in mice.

Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive

This study shows that optogenetic activation of hypothalamic CRH neurons increases stress-related behaviors and reduces sucrose motivation, suggesting a role for these neurons in motivational drive.

Disruption of Tonic Endocannabinoid Signaling Triggers the Generation of a Stress Response

The paper shows that disrupting tonic endocannabinoid signaling increases HPA axis activation by enhancing CRH neuron activity in the PVN, leading to stress-like behaviors and elevated corticosterone.

Adaptive synaptic plasticity maintains CRH neuron output during chronic glucocorticoid exposure

The paper shows CRH neurons adapt to chronic glucocorticoid exposure by increasing synaptic strength to maintain output stability.