Author

Jake J. Siegel

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:yeast· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:eQTL / molecular QTL mapping· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Joshua S. BloomiD· 2 shared Laura Day· 2 shared Leonid KruglyakiD· 2 shared Frank Wolfgang AlbertiD· 1 shared Meru J. SadhuiD· 1 shared Sriram KosuriiD· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Joshua S. BloomORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Genetics of trans-regulatory variation in gene expression

Frank Wolfgang Albert, Joshua S. Bloom, Jake J. Siegel, Laura Day, Leonid Kruglyak

This study identifies eQTLs in yeast to show that most gene expression variation is driven by distant, trans-acting eQTLs clustered at hotspots.

eLife · Jul 16, 2018Peer-reviewedGenetics

Highly parallel genome variant engineering with CRISPR/Cas9 in eukaryotic cells

Meru J. Sadhu, Joshua S. Bloom, Laura Day, Jake J. Siegel, Sriram Kosuri, Leonid Kruglyak

The paper uses CRISPR/Cas9 in yeast to engineer and screen variants, finding most premature termination codons are deleterious except near the C-terminal end.

Nature Genetics · Apr 1, 2018Peer-reviewedGenomics