Frank Wolfgang Albert

High concordance between genetic effects on mRNA and protein abundance

The paper analyzes genetic effects on mRNA and protein abundance across multiple yeast datasets, finding high concordance with few exceptions.

High-resolution, genotype-free mapping of genetic variation with CRI-SPA-Map

The paper introduces CRI-SPA-Map, a genetic mapping strategy in yeast that identifies causal genetic variants for phenotypic differences without genotyping.

Genotype-by-environment interactions shape ubiquitin-proteasome system activity

The paper investigates how genotype-by-environment interactions influence the ubiquitin-proteasome system activity in yeast by analyzing genetic effects across different environments and substrates.

Trans-eQTL hotspots shape complex traits by modulating cellular states

The paper identifies trans-eQTL hotspots in yeast that influence growth traits by altering cellular states through widespread gene expression effects.

Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome

The paper identifies genetic loci influencing milk gene expression and links these to infant gut microbiome composition in breastfeeding mothers.

Human Cytomegalovirus in breast milk is associated with milk composition, the infant gut microbiome, and infant growth

The paper investigates the association between human cytomegalovirus in breast milk and milk composition, infant gut microbiome, and infant growth.

Substrate-Specific Effects of Natural Genetic Variation on Proteasome Activity

The paper identifies 15 genomic loci influencing proteasome activity in yeast using single-cell measurements and CRISPR-based engineering, revealing substrate-specific genetic effects.

Variation in Ubiquitin System Genes Creates Substrate-Specific Effects on Proteasomal Protein Degradation

The paper identifies genetic variants affecting UPS activity in yeast by mapping loci influencing N-degron recognition and ubiquitination.

Multiple causal DNA variants in a single gene affect gene expression in trans

The paper identifies multiple causal DNA variants within a single gene that affect gene expression in trans in yeast, showing complexity in trans-acting variation.

Trans-acting genetic variation affects the expression of adjacent genes

The paper shows trans-eQTLs in yeast can affect adjacent genes through horizontal mechanisms, not just vertical pathways, and this is linked to physical proximity and shared chromatin states.

Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

A CRISPR-based dual reporter assay identifies DNA variants affecting mRNA or protein levels in trans in yeast.

Massively parallel identification of causal variants underlying gene expression differences in a yeast cross

The paper identifies 451 causal regulatory variants in yeast promoters using a massively parallel reporter assay and finds they show epistasis, conservation, and enrichment in transcription factor binding sites.

DNA variants affecting the expression of numerous genes in trans have diverse mechanisms of action and evolutionary histories

The paper identifies three trans-acting variants in yeast that affect gene expression through diverse mechanisms and evolutionary patterns.

Genetics of trans-regulatory variation in gene expression

This study identifies eQTLs in yeast to show that most gene expression variation is driven by distant, trans-acting eQTLs clustered at hotspots.