The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels
Jakob Sauer, Jessica Marksteiner, Martin HOHENEGGER, Hannes Todt, Helmut Kubista, Christopher Dostal, Attila Kiss, Bruno Karl Podesser, Isabella Salzer, Xaver Koenig, Anna Stary‐Weinzinger, Karlheinz Hilber, Oliver Kudlacek
This study shows empagliflozin enhances peak sodium current in Nav1.5 channels by acting as a pharmacological chaperone, potentially reducing arrhythmia risk in Duchenne muscular dystrophy.
American Journal of Physiology-Heart and Circulatory Physiology · Aug 13, 2025Peer-reviewedPharmacology & Toxicology