Bruno Karl Podesser

A novel role for Oxaloacetate Decarboxylase FAHD1 in cardiomyocyte maturation

This study identifies FAHD1 as a critical regulator of mitochondrial function and cardiomyocyte maturation, showing its deficiency impairs respiration, disrupts sarcomere organization, and leads to cardiac dysfunction.

Cardiac GLP1R gene Expression: A Cross-Species Single-Cell Transcriptomic Analysis

This study uses single-cell transcriptomics to compare GLP1R expression in human and mouse cardiac tissues and organoids, finding cardiac expression is low in mice but increased in human heart disease.

Infarctsize-AI: an efficient infarct size image analysis tool for small rodent myocardial infarction studies

Infarctsize-AI reduces time and inter-observer variability in infarct size analysis of rodent myocardial infarction studies using deep learning.

CD8+ T cells regulate the bioenergetic reprogramming of lymphoid organs and the heart during viral infection

This study shows CD8+ T cells drive energy substrate redistribution between lymphoid organs and the heart during viral infection, with metabolic adaptations affecting cardiac function.

The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels

This study shows empagliflozin enhances peak sodium current in Nav1.5 channels by acting as a pharmacological chaperone, potentially reducing arrhythmia risk in Duchenne muscular dystrophy.