The adhesion molecules β7 integrin and L-selectin contribute to cholestatic liver disease in male mice
Agnes Seeger, Anshu Babbar, Sreepradha Eswaran, Maria Adams, Moritz Muschaweck, Nicole Simone Treichel, Thomas Clavel, Guo Yin, Adrien Guillot, Kerstin Scheuer, Sabine Hamm, Jakob-David Adam, Norbert Wagner, Angela Schippers
This study shows that β7 integrin and L-selectin contribute to DDC-induced cholangiopathy in male mice by promoting immune cell infiltration, gut barrier dysfunction, and microbiota shifts.
bioRxiv · Sep 24, 2025 · PreprintImmunology