Author

Jamal Temsamani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Organism:non-human primate· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Géraldine Ferracci· 3 shared Guillaume JacquotiD· 3 shared Marion DavidiD· 3 shared Maxime Masse· 3 shared Michel KhrestchatiskyiD· 3 shared Pascaline Lécorché· 3 shared Stéphane D. GirardiD· 3 shared Andréa Romette· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Géraldine Ferracci

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Harnessing TfR1 for Cross-Species Systemic Delivery of siRNAs to Deep Brain Regions Using Single-Domain Antibodies

Guillaume Jacquot, Marion David, Belinda Pecqueux, Yasmine Mechioukhi, Stéphane D. Girard, Magali Godard, Karine Varini, Cléa Boursery, Cecile FRAPOLLI, Sebastien ROUX, Martin Bigonnet, Béatrice Brousse, Emma Augustin, Gersande Godefroy, Christophe Fraisier, , Michel Khrestchatisky

This paper demonstrates the use of TfR1-targeting single-domain antibodies to deliver siRNAs systemically to deep brain regions, achieving efficient knockdown at low doses.

bioRxiv · May 22, 2026 · PreprintPharmacology & Toxicology

Novel VHH targeting a unique TfR1 epitope for efficient cross-species delivery of drugs in the CNS

Marion David, Romy Cohen, Diane Beuzelin, Géraldine Ferracci, Marina Cresci, Aude Faucon, Karima Abouzid, Gersande Godefroy, Maxime Masse, Yasmine Mechioukhi, Stéphane D. Girard, Ingrid Julien‐Gau, Cléa Boursery, Christophe Fraisier, Karine Varini, , Michel Khrestchatisky

This study identifies cross-species reactive VHHs targeting a novel TfR1 epitope, enabling efficient BBB crossing for CNS drug delivery.

Journal of Controlled Release · Oct 17, 2025Peer-reviewedNeuroscience

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice

Lotfi Ferhat, Rabia Soussi, Maxime Masse, Grigorios Kyriatzis, Stéphane D. Girard, Fanny Gassiot, Nicolas Gaudin, Mathieu Laurencin, Anne Bernard, Angélique Bôle, Géraldine Ferracci, Maria Smirnova, François S. Roman, Vincent Dive, Salvatore Cisternino, , Michel Khrestchatisky

This paper describes a peptide-neurotensin conjugate that crosses the blood-brain barrier and induces pharmacological hypothermia with neuroprotective effects in a mouse model of status epilepticus.

eLife · Mar 28, 2025Peer-reviewedNeuroscience