Pascaline Lécorché

This paper demonstrates the use of TfR1-targeting single-domain antibodies to deliver siRNAs systemically to deep brain regions, achieving efficient knockdown at low doses.

This study identifies cross-species reactive VHHs targeting a novel TfR1 epitope, enabling efficient BBB crossing for CNS drug delivery.

This study shows that specific mutations in the C-terminal domains of MT5-MMP reduce C99 and Aβ levels, suggesting a potential therapeutic strategy for Alzheimer's disease.

This paper describes a peptide-neurotensin conjugate that crosses the blood-brain barrier and induces pharmacological hypothermia with neuroprotective effects in a mouse model of status epilepticus.

This paper investigates the expression and regulation of NTSR2 in rat hippocampal astrocytes and endothelial cells during status epilepticus and neuroinflammation induced by pilocarpine.