Author

Yasmine Mechioukhi

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Organism:non-human primate· 1 Research Focus:protein design· 1

Frequent Co-Authors

Andréa Romette· 2 shared Aude Faucon· 2 shared Bastien SERRANO· 2 shared Christophe FraisieriD· 2 shared Cléa Boursery· 2 shared Diane BeuzeliniD· 2 shared Gauthier Dangla-PélissieriD· 2 shared Géraldine Ferracci· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Andréa Romette

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Harnessing TfR1 for Cross-Species Systemic Delivery of siRNAs to Deep Brain Regions Using Single-Domain Antibodies

Guillaume Jacquot, Marion David, Belinda Pecqueux, Yasmine Mechioukhi, Stéphane D. Girard, Magali Godard, Karine Varini, Cléa Boursery, Cecile FRAPOLLI, Sebastien ROUX, Martin Bigonnet, Béatrice Brousse, Emma Augustin, Gersande Godefroy, Christophe Fraisier, , Michel Khrestchatisky

This paper demonstrates the use of TfR1-targeting single-domain antibodies to deliver siRNAs systemically to deep brain regions, achieving efficient knockdown at low doses.

bioRxiv · May 22, 2026 · PreprintPharmacology & Toxicology

Novel VHH targeting a unique TfR1 epitope for efficient cross-species delivery of drugs in the CNS

Marion David, Romy Cohen, Diane Beuzelin, Géraldine Ferracci, Marina Cresci, Aude Faucon, Karima Abouzid, Gersande Godefroy, Maxime Masse, Yasmine Mechioukhi, Stéphane D. Girard, Ingrid Julien‐Gau, Cléa Boursery, Christophe Fraisier, Karine Varini, , Michel Khrestchatisky

This study identifies cross-species reactive VHHs targeting a novel TfR1 epitope, enabling efficient BBB crossing for CNS drug delivery.

Journal of Controlled Release · Oct 17, 2025Peer-reviewedNeuroscience

Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions

Thibaud Parpaite, Lucie Brosse, Nina Séjourné, Amandine Laur, Yasmine Mechioukhi, Patrick Delmas, Bertrand Coste

The paper combines mechanosensitive current recordings with single-cell RNA sequencing in mouse DRG neurons to identify candidate genes for mechanosensory functions.

Cell Reports · Nov 1, 2021Peer-reviewedNeuroscience