Marion David

This paper develops a VHH-Fc fusion protein to deliver siRNAs and ASOs across the BBB in rodents and NHPs, showing that binding affinity, DAR, and conjugation site affect delivery efficiency.

This paper demonstrates the use of TfR1-targeting single-domain antibodies to deliver siRNAs systemically to deep brain regions, achieving efficient knockdown at low doses.

This study shows that improving angiogenesis enhances ASO-based exon-skipping therapy in DMD by increasing ASO delivery and dystrophin expression in mdx mice.

This study identifies cross-species reactive VHHs targeting a novel TfR1 epitope, enabling efficient BBB crossing for CNS drug delivery.

This study shows that specific mutations in the C-terminal domains of MT5-MMP reduce C99 and Aβ levels, suggesting a potential therapeutic strategy for Alzheimer's disease.

This paper describes a peptide-neurotensin conjugate that crosses the blood-brain barrier and induces pharmacological hypothermia with neuroprotective effects in a mouse model of status epilepticus.