Programmable CRISPRtune dissects the transcriptional repressive activity of MeCP2
Jinna I. Brim, Izaiah J. Ornelas, Peter J. Colias, Nikita S. Divekar, Da Xu, Justin P. Lubin, Sophia I Ferrel, Luis G Palma, Mitzi G Hernández Zamora, Rithu K. Pattali, Jameel J McDaniel, Sarah Chasins, James K. Nuñez
CRISPRtune is a programmable tool that tunes transcriptional repression by fusing MeCP2 to dCas9, enabling intermediate gene expression control in human cells.
bioRxiv · Jul 10, 2026 · PreprintGenomics